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Gentle Method to Detect Amyloidosis Found

Approximately 30 different amyloid proteins form, disburse and congregate in body tissues. Under normal circumstances the body eliminates these compounds when they are no longer needed. However, as we age, the proteins tend to clump and elimination methods become less effective. These areas of protein accumulation cause tissue damage that lead to the development of many different health conditions commonly referred to as amyloidosis, which can lead to the development of Alzheimer’s and dementia. The following study details the creation of a less invasive method to detect these amyloids to benefit seniors with dementia and their Alzheimer’s caregivers in Sacramento.

Up until recently, the only method of detecting amyloidosis involved staining tissue samples with Congo red. The dye causes the protein deposits to glow or fluoresce, which makes them visible using high-powered molecular microscopes. However, this method is not foolproof. A group of researchers from Sweden’s Linkoping University developed a more accurate way of detecting the presence of amyloids using a more sensitive molecular chemical probe.

Using the newly designed probe, researchers were more readily able to detect protein accumulations in samples that were previously deemed as being amyloid-free. The new probe functions similar to previous staining and fluorescent methods. However, the process is able to locate and bind with smaller deposits. Future endeavors may one day be able to differentiate between the types of amyloid proteins in addition to where and why they congregate. 

The discovery raises the possibility that patients might undergo screening evaluation for the presence of amyloid-related diseases before symptoms or irreversible tissue damage occurs. Physicians may then formulate a preventative treatment plan, which might delay the need for dementia home care in Sacramento after an amyloidosis diagnosis. The U.S. Office of Rare Diseases reports that amyloidosis disease processes are thought to affect 200,000 people in the country. However, representatives of the Amyloidosis Foundation believe that this number may be too low. With advances in the ability to detect and identify the individual proteins, heath care providers might learn that the development of disease processes formerly thought to emerge from other factors may actually be caused by amyloid protein clumping. 

Amyloidosis often leads to degenerative disorders such as dementia and Alzheimer’s disease, which can be challenging for seniors to manage alone. Home Care Assistance provides compassionate Alzheimer’s and dementia elder care Sacramento seniors trust to manage daily activities such as cooking, bathing, and exercise throughout each stage of the disease. Call us today at 916.706.0169 to speak with a knowledgeable Care Manager and schedule a complimentary consultation.